In situ structure and organization of the influenza C virus surface glycoprotein

Influenza C virus contains a single Laundry Storage Basket surface glycoprotein, the haemagglutinin-esterase-fusion (HEF) protein, that mediates receptor binding, receptor destruction, and membrane fusion activities.Here, the authors apply electron cryotomography of Bartöl whole virus together with subtomogram averaging to determine the HEF structure and lattice organisation on the viral membrane and they discuss mechanistic implications for virus budding and membrane fusion.